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To ensure homogeneous conditions within the complete area of perfusedmicrofluidic bio-reactors, we develop a general design of a continuously feedbio-reactor with uniform perfusion flow. This is achieved by introducing aspecific type of perfusion inlet to the reaction area. The geometry of theseinlets are found using the methods of topology optimization and shapeoptimization. The results are compared with two different analytic models, fromwhich a general parametric description of the design is obtained and testednumerically. Such a parametric description will generally be beneficial for thedesign of a broad range of microfluidic bioreactors used for e.g. cellculturing and analysis, and in feeding bio-arrays.

Optimal homogenization of perfusion flows in microfluidic bio-reactors; a numerical study