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Nuclear physics offers us a powerful tool: using nuclear resonance absorptionlines to infer the physical conditions in astrophysical settings which areotherwise difficult to deduce. Present-day technology provides an increase insensitivity over previous gamma-ray missions large enough to utilize this toolfor the first time. The most exciting promise is to measure gamma-ray burstsfrom the first star(s) at redshifts 20-60, but also active galactic nuclei arepromising targets.

Nuclear Resonances: The quest for large column densities and a new tool