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We test the claim by Yu et al. -- presented in Science 322, 104 (2008) --that the degree distribution of the yeast (Saccharomyces cerevisiae)protein-interaction network is best approximated by a power law. Yu et al.consider three versions of this network. In all three cases, however, we findthe most likely power-law model of the data is distinct from and incompatiblewith the one given by Yu et al. Only one network admits good statisticalsupport for any power law, and in that case, the power law explains only thedistribution of the upper 10% of node degrees. These results imply that thereis considerably more structure present in the yeast interactome than suggestedby Yu et al., and that these networks should probably not be called "scalefree."

Comment on Yu et al., "High Quality Binary Protein Interaction Map of the Yeast Interactome Network." Science 322, 104 (2008)