English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Protein electrostatics have been demonstrated to play a vital role in proteinfunctionality, with many functionally important amino acid residues exhibitingan electrostatic state that is altered from that of a normal amino acidresidue. Residues with altered electrostatic states can be identified by thepresence of a pKa value that is perturbed by 2 or more pK units, and suchresidues have been demonstrated to play critical roles in catalysis, ligandbinding, and protein stability. Within the HCV helicase and polymerase, as wellas the HIV reverse transcriptase, highly conserved regions were demonstrated topossess a greater number and magnitude of perturbations than lesser conservedregions, suggesting that there is an interrelationship present between proteinelectrostatics and evolution.

Interrelationship Between Protein Electrostatics and Evolution in HCV and HIV Replicative Proteins