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Protein electrostatic states have been demonstrated to play crucial roles incatalysis, ligand binding, protein stability, and in the modulation ofallosteric effects. Electrostatic states are demonstrated to appear conservedamong DEAD-box motifs and evidence is presented that the structural changesthat occur to DEAD box proteins upon ligand binding alter the DEAD-box motifelectrostatics in a way the facilitates the catalytic role of the DEAD-boxglutatmate.

The Role of Protein Electrostatics in Facilitating the Catalysis of DEAD-box Proteins