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The phenomenon of gene conservation is an interesting evolutionary problemrelated to speciation and adaptation. Conserved genes are acted upon inevolution in a way that preserves their function despite other structural andfunctional changes going on around them. The recent availability ofwhole-genomic data from closely related species allows us to test thehypothesis that a core genome present in a hypothetical common ancestor isinherited by all sister taxa. Furthermore, this core genome should serveessential functions such as genetic regulation and cellular repair.Whole-genome sequences from three strains of bacteria (Shewanella sp.) wereused in this analysis. The open reading frames (ORFs) for each identified andputative gene were used for each genome. Reciprocal Blast searches wereconducted on all three genomes, which distilled a list of thousands of genes to68 genes that were identical across taxa. Based on functional annotation, thesegenes were identified as housekeeping genes, which confirmed the originalhypothesis. This method could be used in eukaryotes as well, in particular therelationship between humans, chimps, and macaques.

Towards a core genome: pairwise similarity searches on interspecific genomic data