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In our last paper, we have reported the direct interact between energeticions and DNA, and its components, pointing out that damage to DNA is actuallyof highest biological consequence, as the integrity of DNA sequence isessential for biological function. Proteins are another kind of importantbiomolecules. Although much recent attention has been payed to ion irradiationinitiated reaction cascades leading to DNA damage, the protein lesions inducedby energetic ions remain virtually unexplored at the molecular scale (maybebecause there are usually many copies of each protein, so a comparable level ofdamage is of much less biological impact). Except for DNA damage, anunderstanding of nascent events leading to radiolytic protein damage is alsorequired in order to achieve a complete description of ionizing radiationeffects on living cells.

Ion irradiation induced direct damage to proteins and their components