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Existence of metastable quarks of new generation can be embedded intophenomenology of heterotic string together with new long range interaction,which only this new generation possesses. We discuss primordial quarkproduction in the early Universe, their successive cosmological evolution andastrophysical effects, as well as possible production in present or futureaccelerators. In case of a charge symmetry of 4th generation quarks inUniverse, they can be stored in neutral mesons, doubly positively chargedbaryons, while all the doubly negatively charged "baryons" are combined withHe-4 into neutral nucleus-size atom-like states. The existence of all theseanomalous stable particles may escape present experimental limits, being closeto present and future experimental test. Due to the nuclear binding with He-4primordial lightest baryons of the 4th generation with charge +1 can alsoescape the experimental upper limits on anomalous isotopes of hydrogen, beingcompatible with upper limits on anomalous lithium. While 4th quark hadrons arerare, their presence may be nearly detectable in cosmic rays, muon and neutrinofluxes and cosmic electromagnetic spectra. In case of charge asymmetry, anontrivial solution for the problem of dark matter (DM) can be provided byexcessive (meta)stable anti-up quarks of 4th generation, bound with He-4 inspecific nuclear-interacting form of dark matter. Such candidate to DM issurprisingly close to Warm Dark Matter by its role in large scale structureformation. It catalyzes primordial heavy element production in Big BangNucleosynthesis and new types of nuclear transformations around us.

Stable quarks of the 4th family?