English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

We consider the dynamics of a non-recombining haploid population of finitesize which accumulates deleterious mutations irreversibly. This ratchet likeprocess occurs at a finite speed in the absence of epistasis, but it has beensuggested that synergistic epistasis can halt the ratchet. Using a diffusiontheory, we find explicit analytical expressions for the typical time betweensuccessive clicks of the ratchet for both non-epistatic and epistatic fitnessfunctions. Our calculations show that the inter-click time is of a scaling formwhich in the absence of epistasis gives a speed that is determined by size ofthe least-loaded class and the selection coefficient. With synergisticinteractions, the ratchet speed is found to approach zero rapidly for arbitraryepistasis. Our analytical results are in good agreement with the numericalsimulations.

Loss of least-loaded class in asexual populations due to drift and epistasis