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Hot spots in tumors are regions of high vascular density in the center of thetumor and their analysis is an important diagnostic tool in cancer treatment.We present a model for vascular remodeling in tumors predicting that theformation of hot spots correlates with local inhomogeneities of the originalarterio-venous vasculature of the healthy tissue. Probable locations for hotspots in the late stages of the tumor are locations of increased blood pressuregradients. The developing tumor vasculature is non-hierarchical but stillcomplex displaying algebraically decaying density distributions.

Hot spot formation in tumor vasculature during tumor growth in an arterio-venous-network environment