English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Although conservation of thermodynamics is much less studied than ofsequences and structures, thermodynamic details are biophysical featuresdifferent from but as important as structural features. As a succession ofprevious research which revealed the important relationships betweenthermodynamic features and miRNA maturization, this article appliesinterspecies conservation of miRNA thermodynamics and structures to study miRNAmaturization. According to a thermodynamic and structural consensus principle,miRBase is categorized by conservation subgroups, which imply variousfunctions. These subgroups are divided without the introduction of functionalinformation. This suggests the consistency between the two processes of miRNAmaturization and functioning. Different from prevailing methods which predictextended miRNA precursors, a learning-based algorithm is proposed to predict~22bp mature parts of 2780 test miRNA genes in 44 species with a rate of 79.4%.This is the first attempt of a general interspecies prediction of maturemiRNAs. Suboptimal structures that most fit the consensus thermodynamic andstructural profiles are chosen to improve structure prediction. Distribution ofmiRNA locations on corresponding pri-miRNA stem-loop structures is thenstudied. Existing research on Drosha cleavage site is not generally true acrossspecies. Instead, the distance between mature miRNA and center loop normalizedby stem length is a more conserved structural feature in animals, and thenormalized distance between mature miRNA and ss-RNA tail is the counterpart inplants. This suggests two possibly-updating mechanisms of miRNA maturization inanimals and plants. All in all, conservations of thermodynamics together withother features are shown closely related to miRNA maturization.

Thermodynamic and structural consensus principle predicts mature miRNA  location and structure, categorizes conserved interspecies miRNA subgroups,  and hints new possible mechanisms of miRNA maturization