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We report 10 successfully folding events of trpzip2 by molecular dynamicssimulation. It is found that the trizip2 can fold into its native state throughdifferent zipper pathways, depending on the ways of forming hydrophobic core.We also find a very fast non-zipper pathway. This indicates that there may beno inconsistencies in the current pictures of beta-hairpin folding mechanisms.These pathways occur with different probabilities. zip-out is the most probableone. This may explain the recent experiment that the turn formation is therate-limiting step for beta-hairpin folding.

Observation of Multiple folding Pathways of beta-hairpin Trpzip2 from Independent Continuous Folding Trajectories