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Chargaff's second parity rule holds empirically for most types of DNA thatalong single strands of DNA the base contents are equal for complimentarybases, A = T, G = C. A Markov chain model is constructed to track the evolutionof any single base position along single strands of genomes whose organisms areequipped with replication mismatch repair. Under the key assumptions thatmismatch error rates primarily depend the number of hydrogen bonds ofnucleotides and that the mismatch repairing process itself makes strandrecognition error, the model shows that the steady state probabilities for anybase position to take on one of the 4 nucleotide bases are equal forcomplimentary bases. As a result, Chargaff's second parity rule is themanifestation of the Law of Large Number acting on the steady stateprobabilities. More importantly, because the model pinpoints mismatch repair asa basis of the rule, it is suitable for experimental verification.

Mismatch Repair Error Implies Chargaff's Second Parity Rule