Open AccessRevive Herbal Capsule: A Review on the Mechanism of Action, Constituent Herbs and Phytochemicals
Author(s) -
Onengiyeofori Ibama,
Aleruchi-Didia Tarila Ngowari,
Jonathan Nyebuchi,
Onengiye Davies-Nwalele
Publication year - 2021
Publication title -
journal of complementary and alternative medical research
Language(s) - English
Resource type - Journals
ISSN - 2456-6276
DOI - 10.9734/jocamr/2021/v16i130278
Subject(s) - tribulus terrestris , traditional medicine , medicine , phytochemical , ginseng , erectile dysfunction , capsule , pharmacology , eucommia ulmoides , aphrodisiac , herb , traditional chinese medicine , medicinal herbs , surgery , biology , botany , alternative medicine , pathology
Revive capsule, also called Kedi Revive capsule is a polyherbal formulation manufactured by Kedi healthcare company limited in Hong Kong, China. The drug is widely used around the globe, especially in Africa and Asia for the treatment of erectile dysfunction or enhancement of libido in men. Each capsule contains 400 mg of the constituent herbs including 80 mg of herb Epimedii, 80mg of Radix ginseng, 40 mg of Cordyceps militaris, 80mg of Tribulus terrestris, 80mg of Radix polygoni multiflori, and 40 mg of Eucommia ulmoides, with its effects exerted four hours after administration via the oral route. The adult man dosage is two capsules (800 mg) to be taken once daily for at least 28 days (before significant improvements may be observed when used to treat erectile dysfunction). Phytochemical analysis of the drug reported the presence of flavonoids, cardiac glycosides, tannins, polyphenols, alkaloids and quinones. Due to its speculated use in the treatment of erectile dysfunction or enhancement of libido, it may be referred to as an herbal phosphodiesterase type-5 inhibitor, that acts by selectively inhibiting the enzyme phosphodiesterase type-5, and thus enhancing increased arterial blood flow into the penis, which results in penile erection; however, the mechanism of action of this drug may be attributed to the contained phytochemicals. Additionally, due to its increased use, it is highly recommended that further studies be conducted on this drug to ascertain its effects on some biochemical components and vital organs of the body.