Premium
Duplex Doppler ultrasonographic comparison of the effects of propranolol and isosorbide‐5‐mononitrate on portal hemodynamics
Author(s) -
Tincani E,
Cioni G,
Cristani A,
D'Alimonte P,
Vignoli A,
Abbati G,
Ventura P,
Romagnoli R,
Ventura E
Publication year - 1993
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.7863/jum.1993.12.9.525
Subject(s) - medicine , isosorbide mononitrate , propranolol , esophageal varices , isosorbide , isosorbide dinitrate , hemodynamics , varices , varix , doppler sonography , cardiology , anesthesia , portal hypertension , cirrhosis , chemistry , organic chemistry
Eighteen cirrhotic patients with esophageal varices at risk for bleeding took part in a double‐blind study. The variations in PFV induced by either 40 mg of propranolol or 60 mg of sustained‐release isosorbide‐5‐mononitrate on two consecutive days were evaluated with a duplex Doppler device. Both drugs caused a significant decrease in maximum (propranolol, P = 0.002; isosorbide‐5‐mononitrate, P = 0.021). Four patients responded to propranolol, three to isosorbide‐5‐mononitrate, and eight to both drugs; three did not show any change. Duplex Doppler sonography may be of use in the selection of the right pharmacologic treatment for the individual patient for the prevention of a bleeding esophageal varix.