Open AccessDysregulation of Glucose Homeostasis Following Chronic Exogenous Administration of Leptin in Healthy Sprague-Dawley Rats
Author(s) -
Khalil Wjidan,
Effendi Ibrahim,
Brinnell Caszo,
Justin Gnanou,
Harbindar Jeet Singh Gurcharan Singh
Publication year - 2015
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2015/15594.7003
Subject(s) - medicine , endocrinology , leptin , insulin , glucose transporter , glucose homeostasis , insulin resistance , skeletal muscle , diabetes mellitus , obesity
Impaired glucose utilization is seen in chronic hyperleptinaemia associated conditions such as obesity and type 2 diabetes mellitus. It is unclear if this impaired glucose utilization is due to the effect of persistent hyperleptinaemia on insulin secretion from the beta cells of pancreas.