Open AccessA Rare Presentation of Gastric Signet Ring Cells: Signet Ring Cell Lymphoma
Author(s) -
Sithara Venkateshwar,
Tobias Alexander,
Marie Moses Ambroise,
Renu G’Boy Varghese,
Anita Ramdas
Publication year - 2014
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2014/10811.5323
Subject(s) - signet ring cell , pathology , stain , lymphoma , immunohistochemistry , stomach , ring (chemistry) , cd20 , medicine , chemistry , adenocarcinoma , staining , cancer , organic chemistry
We herewith present a rare and interesting case of gastric signet ring cell lymphoma (SRCL) in a 40-year-old retroviral positive lady. SRCL is a rare morphological variant of nodal lymphomas.Biopsy from the suspected lesion in the stomach showed diffuse sheets of cells with a large central vacuole displacing the nucleus to the periphery of the cell, imparting signet ring cell morphology. Negative reaction to PAS (Periodic acid Schiff) stain and subsequent strong positivity for the immunohistochemical markers such as CD45 (Leucocyte commonantigen) and CD20, a B-cell marker helped us to arrive at a diagnosis of signet ring B- cell lymphoma.