Open AccessP53 Arg72Pro and MDM2 SNP309 Polymorphisms Cooperate to Increase Lung Adenocarcinoma Risk in Chinese Female Non-smokers: A Case Control Study
Author(s) -
Yong Ren,
Zhihua Yin,
Yan Wan,
Peng Guan,
Wei Wu,
Xuelian Li,
Baosen Zhou
Publication year - 2013
Publication title -
asian pacific journal of cancer prevention
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 75
eISSN - 2476-762X
pISSN - 1513-7368
DOI - 10.7314/apjcp.2013.14.9.5415
Subject(s) - genotype , lung cancer , single nucleotide polymorphism , adenocarcinoma , carcinogenesis , mdm2 , medicine , oncology , snp , genotyping , cancer research , gastroenterology , biology , cancer , genetics , gene
Cell cycle deregulation is a major component of carcinogenesis. The p53 tumor suppressor gene plays an important role in regulating cell cycle arrest, and mouse double minute 2 (MDM2) is a key regulator of p53 activity and degradation. Abnormal expression of p53 and MDM2 occurs in various cancers including lung cancer.