Open AccessHigh Incidence of Contaminating Maternal Cell Overgrowth in Human Placental Mesenchymal Stem/Stromal Cell Cultures: A Systematic Review
Author(s) -
Heazlewood Celena F.,
Sherrell Helen,
Ryan Jennifer,
Atkinson Kerry,
Wells Christine A.,
Fisk Nicholas M.
Publication year - 2014
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2014-0051
Subject(s) - mesenchymal stem cell , chorionic villi , placenta , fetus , andrology , pregnancy , medicine , stromal cell , stem cell , obstetrics , biology , immunology , physiology , pathology , microbiology and biotechnology , genetics
Establishing the prevalence of maternal contamination has clear implications for the robustness and validity of both preclinical studies and clinical trials using placental mesenchymal stem/stromal cells (MSCs). Accordingly, we undertook a systematic review of studies investigating human placental and/or chorionic MSCs to determine the frequency and purity of maternal contamination in cultured placental chorion MSCs populations and clinical and laboratory correlates associated with maternal contamination.
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