Preliminary study of physiopathological changes associated with the ethanolic extract of the stem leaves of Phyllanthus amarus in rats

The present work aimed to investigate physiopathological changes associated with the ethanolic extract of the stem leaves of Phyllanthus amarus (EEt(OH) P.a. Exploratory tests are performed in vivo on Wistar albino rats. Analysis of the variation in body weight at the level of the batch having received, and the control group showed a slight weight drop 7 d after treatment. This variation is not significant (p>0.05). The means relative organ weights show that there were no significant changes between control and treated groups (P ˃ 0.05).   No obvious clinical signs (tremor, breathing rate, paralysis). Slightly greater differences were noted for WBC of the Control group and rats treaded with EEt(OH) P.a (5000 mg/kg b.w.) on day 14 after the administration. These differences were statistically significant (p 0.05) in glucose, total protein, urea, creatinine levels  between control and experiemental groups at 14 d. Total bilirubin (TBIL) and Indirect bilirubin (IBIL), however, were statistically significant (p 0.05) in test and control batch. Key words: Phyllanthus amarus Schum. & Thonn., physiopathological, breathing rate, paralysis, bilirubin, alanine amino, transferase, creatinine, alkaline, phosphatase, transaminases, aspartate amino.