Open AccessComparison of Amikacin Pharmacokinetics in Neonates With and Without Congenital Heart Disease
Author(s) -
Amy L. Nguyen,
Peter N. Johnson,
Stephen Neely,
Kaitlin M. Hughes,
Krishnamurthy Sekar,
Robert C. Welliver,
Jamie L. Miller
Publication year - 2021
Publication title -
the journal of pediatric pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.456
H-Index - 15
eISSN - 2331-348X
pISSN - 1551-6776
DOI - 10.5863/1551-6776-26.4.372
Subject(s) - medicine , amikacin , gestational age , incidence (geometry) , heart disease , retrospective cohort study , logistic regression , pediatrics , pregnancy , antibiotics , physics , optics , biology , microbiology and biotechnology , genetics
The primary objective was to compare the volume of distribution (Vd), clearance (CL), elimination rate (K e ), and half-life (t½) of amikacin in neonates with cyanotic defects, acyanotic defects, and controls, adjusted for gestational and postnatal age. Secondary objectives were to compare the incidence of acute kidney injury (AKI) between controls and the congenital heart disease (CHD) group and to identify potential risk factors.