Open AccessElectrochemical sensing platform for simultaneous detection of 6-mercaptopurine and 6-thioguanine using RGO-Cu2O/Fe2O3 modified screen-printed graphite electrode
Author(s) -
Fatemeh Irannezhad,
Jamileh Seyed-Yazdi,
Seyedeh Hoda Hekmatara
Publication year - 2021
Publication title -
journal of electrochemical science and engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.236
H-Index - 6
ISSN - 1847-9286
DOI - 10.5599/jese.1101
Subject(s) - graphene , graphite , materials science , fourier transform infrared spectroscopy , detection limit , nanocomposite , electrode , electrochemical gas sensor , differential pulse voltammetry , scanning electron microscope , electrochemistry , analytical chemistry (journal) , oxide , nuclear chemistry , nanotechnology , cyclic voltammetry , chemical engineering , chemistry , chromatography , composite material , metallurgy , engineering
A sensitive electrochemical sensor was developed using reduced graphene oxide RGO-Cu2O/Fe2O3 nanocomposite for 6-mercaptopurine detection based on a facile fabrication method. The surface morphology and structural composition of this nanocomposite was evaluated by X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), and Fourier transform infrared (FT-IR) spectroscopy. The screen-printed graphite electrode (SPGE) modified with RGO-Cu2O/Fe2O3 nanocomposite (RGO-Cu2O/Fe2O3/SPGE) indicated excellent electrochemical properties to detect 6-mercaptopurine. The linear dynamic range was estimated between 0.05 and 400.0 μM for 6-mercaptopurine detection, with a limit of detection of 0.03 μM. Also, RGO-Cu2O/Fe2O3/SPGE sensor showed good activity for simultaneous detection of 6-mercaptopurine and 6-thioguanine. In the coexistence system of 6-mercaptopurine and 6-thioguanine, two clear and well-isolated voltammetric peaks were obtained by differential pulse voltammetry (DPV). Additionally, the proposed sensor was examined for applicability by determining 6-mercaptopurine and 6-thioguanine in real samples, and the recovery in the range of 97.5-103.0 % was obtained.