Open AccessSynthesis and diverse biological activity profile of triethylammonium isatin-3-hydrazones
Author(s) -
А. В. Богданов,
О. М. Цивилева,
Alexandra D. Voloshina,
Anna P. Lyubina,
Syumbelya K. Amerhanova,
Ekaterina Burtceva,
С. В. Бухаров,
А. В. Самородов,
В. Н. Павлов
Publication year - 2022
Publication title -
admet and dmpk
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.309
H-Index - 13
ISSN - 1848-7718
DOI - 10.5599/admet.1179
Subject(s) - isatin , bacillus cereus , chemistry , staphylococcus aureus , antibacterial activity , antimicrobial , stereochemistry , organic chemistry , bacteria , biology , genetics
A series of biorelevant triethylammonium isatin hydrazones containing various substituents in the aromatic fragment have been synthesized. Their structure and composition were confirmed by NMR- and IR-spectroscopies, mass-spectrometry and elemental analysis. It was found that some representatives show activity against Staphylococcus aureus and Bacillus cereus higher or at the level of norfloxacin, including methicillin-resistant Staphylococcus aureus strains. The study also showed low hemo- and cytotoxicity (Chang Liver) and high antiaggregatory and anticoagulant activity of these compounds. The high potential of new ammonium isatin-3-acylhydrazones in the search for antimicrobial activity against phytopathogens of bacterial and fungal nature has been shown for the first time.