Open AccessAcute kidney injury during treatment for latent tuberculous infection with rifampin
Author(s) -
Jonathan M. Wortham,
Marie Goggin,
Carmen Mora,
L Vandehey,
Lilia P. Manangan,
Krista M. Powell
Publication year - 2017
Publication title -
the international journal of tuberculosis and lung disease/the international journal of tuberculosis and lung disease. articles traduits en français ...
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.103
H-Index - 110
eISSN - 1815-7920
pISSN - 1027-3719
DOI - 10.5588/ijtld.17.0003
Subject(s) - medicine , acute kidney injury , intensive care medicine , tuberculosis , adverse effect , latent tuberculosis , hemodialysis , nephropathy , kidney disease , pathology , mycobacterium tuberculosis , diabetes mellitus , endocrinology
Treatment for latent tuberculous infection (LTBI) is a key strategy for the elimination of tuberculosis. Rare adverse reactions associated with LTBI treatment have been reported. We report the only case of acute kidney injury reported to Centers for Disease Control and Prevention surveillance for LTBI treatment-related adverse events. The patient experienced rapid intravascular hemolysis, resulting in heme pigment nephropathy; he was hospitalized and received three hemodialysis treatments, but recovered without sequelae. While LTBI treatment-related adverse events are rare, health care providers should maintain clinical vigilance and regularly counsel patients to facilitate prompt diagnoses and effective clinical management of affected patients.