Open AccessActivation of caspase-1 is mediated by stimulation of interferon genes and NLR family pyrin domain containing 3 in monocytes of active systemic lupus erythematosus
Author(s) -
Shoichiro Inokuchi,
Hiroki Mitoma,
S. Kawano,
Masahiro Ayano,
Yasutaka Kimoto,
Mitsuteru Akahoshi,
Yojiro Arinobu,
Koichi Akashi,
Takahiko Horiuchi,
Hiroaki Niiro
Publication year - 2022
Publication title -
clinical and experimental rheumatology
Language(s) - English
Resource type - Journals
eISSN - 1593-098X
pISSN - 0392-856X
DOI - 10.55563/clinexprheumatol/eakvlv
Subject(s) - pyrin domain , inflammasome , medicine , immunology , cd14 , caspase 1 , cd16 , monocyte , inflammation , flow cytometry , immune system , cd8 , cd3
Emerging evidence has shown the importance of inflammasome activation in the progression of autoimmune diseases. In this study, we aimed to identify the main cell types activating inflammasome in autoimmune diseases and to clarify the intracellular pathway of inflammasome activation in systemic lupus erythematosus (SLE).