Open AccessSimple two spectrophotometric methods for estimation of Cephalexin in pure and pharmaceutical dosage form
Author(s) -
Neda Ibrahim Mahdi
Publication year - 2021
Publication title -
mağallaẗ sāmarrāʾ al-ʿulūm al-ṣirfaẗ wa-al-taṭbīqiyyaẗ
Language(s) - English
Resource type - Journals
eISSN - 2789-6838
pISSN - 2663-7405
DOI - 10.54153/sjpas.2021.v3i1.166
Subject(s) - dosage form , zero order , linearity , pharmaceutical formulation , chromatography , detection limit , mathematics , chemistry , first order , physics , quantum mechanics
This study describes two extraction-free and direct spectrophotometric methods for the determination of Cephalexin in a pure and pharmaceutical dosage form. In this study, a zero-order method has exhibited maximum absorption max at 263 nm, while area under curve method has calculated in the range 260-266nm. The Linearity of both methods in the range (10- 60 nm), the limit of detection (LOD) is 0.808 for Zero-order method and 0.781 for the area under curve method. These methods are successfully applied to determination of Cephalexin in a pharmaceutical dosage form.