Open AccessEfficacy and safety of Trang Phuc Linh Plus tablets in patients with irritable bowel syndrome-diarrhea
Author(s) -
Pham Thi Van Anh,
Nguyễn Phương Thanh,
Dau Thuy Duong,
Nguyễn Thị Diệu Thúy,
Dang Thi Ngoc,
Nguyen Duc Linh,
Nguyên Quang Thái,
Hoang Xuan Ba,
Hoang Thi Huong,
Trần Ngọc Ánh,
Duong Cong Thanh,
Nguyễn Thị Phương Anh
Publication year - 2021
Publication title -
nghiên cứu y học
Language(s) - English
Resource type - Journals
ISSN - 2354-080X
DOI - 10.52852/tcncyh.v148i12.588
Subject(s) - irritable bowel syndrome , discontinuation , medicine , diarrhea , tolerability , adverse effect , placebo , gastroenterology , alternative medicine , pathology
A double-blind, randomized, phase II clinical trial was conducted within a 14-week follow-up including 2 weeks of the non-drug run-in period, 8 weeks of medication, and 4 weeks of follow-up after discontinuation. The objective of the study was to evaluate the efficacy and safety of Trang Phuc Linh Plus in irritable diarrhea syndrome patients. Group I took Trang Phuc Linh Plus 3 tablets/time x 2 times/day for 8 weeks; Group II took placebo 3 tablets/time x 2 times/day for 8 weeks. Patients will be re-examined, tested, and evaluated over the phone for symptom recurrence and adverse events (AEs). This study showed that the Trang Phuc Linh Plus tablets tended to improve symptoms in patients suffering from irritable bowel syndrome with diarrhea, suggesting its safety and tolerability.