Open AccessAcute and subchronic oral toxicities of “Da day An Chau” tablets in experimental animals
Author(s) -
Trần Thanh Tùng,
Dao Viet Hoang,
Pham Thi Van Anh,
Dang Thi Thu Hien
Publication year - 2021
Publication title -
nghiên cứu y học
Language(s) - English
Resource type - Journals
ISSN - 2354-080X
DOI - 10.52852/tcncyh.v141i5.207
Subject(s) - toxicity , acute toxicity , body weight , medicine , median lethal dose , lethal dose , pharmacology , physiology , toxicology , biology
In this study, the toxicities of “Da day An Chau” tablets (DDAC) were assessed on experimental animals. To evaluate the acute toxicity on Swiss mice according to World Health Organization Guidance and to determine LD50 refer to the method of Litchfield – Wilcoxon. The subchronic toxicity study of DDAC at two doses (0.58 g/kg/day and 1.74 g/kg/day) was conducted in rats for four consecutive weeks. Evaluation of general conditions and weight of rats during the study period. Rat’s blood was taken for hematological and biochemical evaluations. The livers and kidneys microscopes were evaluated at the end of the experiment. The result revealed that mice were taken up to a maximum dose of 25.71 g/kg with no symptoms of acute toxicity; LD50 of DDAC has not been determined. At two doses, the subchronic toxicity study did not change rats’ body weight, hematological, biochemical parameters, and microscopic of the livers and kidneys during the study period.