Open AccessMorphological changes in the skin and subcutaneous tissue during the creation of an experimental model of lymphedema on the hind limb of a white rat
Author(s) -
V. F. Baytinger,
И. В. Суходоло,
O. S. Kurochkina,
M. E. Pavlova,
Yury V. Kistenev,
Н. А. Кривова,
A. V. Taletskiy,
Viktor V. Nikolaev
Publication year - 2022
Publication title -
voprosy rekonstruktivnoj i plastičeskoj hirurgii
Language(s) - English
Resource type - Journals
ISSN - 1814-1471
DOI - 10.52581/1814-1471/80/05
Subject(s) - lymphatic system , lymphedema , hindlimb , dermis , edema , subcutaneous tissue , anatomy , pathology , medicine , surgery , cancer , breast cancer
The paper describes the reconstruction of the rat hind limb lymphedema model according to the method of V. Triacca et al. (2019), presents in detail morphological changes in the skin and subcutaneous tissue of animals at different stages of the development of chronic lymphatic edema. Histological changes in the tissues of the dermis and hypodermis up to 3 months are characteristic of acute lymphatic edema, from the 4th to the 6th month the histological picture is characteristic of the compensation stage. The most pronounced changes characteristic of chronic lymphatic edema develop by the 6th month.