Open AccessEVALUATION OF OXIDATIV STATE PROTEINASE-INHIBITORY SYSTEM AND ENDOTOXICOSIS IN PATIENTS WITH COPD
Author(s) -
О. А. Lykholat,
Olena Strochka,
Maryna Kudryavtseva
Publication year - 2021
Publication title -
interconf
Language(s) - English
Resource type - Journals
ISSN - 2709-4685
DOI - 10.51582/interconf.19-20.09.2021.022
Subject(s) - copd , oxidative stress , pathogenesis , pathological , inflammation , medicine , disease , lipid peroxidation , endocrinology , physiology , immunology
The aim of the work was to study the relationship between indicators of proteinase-inhibitory system, oxidative stress and endotoxicosis in patients with COPD. 67 patients with COPD, men with an average age of 53.12.2 years, with the duration of the disease on average 12.51.7 years, in the stable phase of the pathological process with II-IV degrees of ventilation disorders according to the GOLD were examined. The activation of trypsin as an indicator of the state of the proteinase-inhibitory system involved in bronchopulmonary diseases pathogenesis, a probable decrease in the activity of its obligate α1-antitrypsin inhibitor, lipid peroxidation secondary metabolites accumulation, total antioxidant activity, molecules of average weight level increase in serum of COPD patients were found. At the examined patients endotoxicosis with initiation of disturbances of mechanisms of recovery in bronchopulmonary system is noted. Together, these events lead to a vicious circle of persistent inflammation, accompanied by chronic oxidative stress and the process persistence. In our opinion, further studies should focus on identifying the molecular mechanisms determining the heterogeneity of COPD progression, since it is known that in some patients the disease can progress rapidly, while other patients may remain relatively stable for many years.