Open AccessЦИТОГЕНЕТИЧЕСКИЕ ЭФФЕКТЫ РЕСВЕРАТРОЛА И КАНДЕСАРТАНА <i>IN</i> <i>VIVO</i> И <i>IN</i> <i>VITRO</i>
Author(s) -
A. Beliayeva,
I. S. Dorofeyenko,
М. В. Анисович,
A. K. Vlasenko,
V. B. Sazanov,
V. Yu. Afonin,
V. V. Shilov
Publication year - 2013
Publication title -
problemy zdorovʹâ i èkologii
Language(s) - English
Resource type - Journals
eISSN - 2708-6011
pISSN - 2220-0967
DOI - 10.51523/2708-6011.2013-10-4-19
Subject(s) - in vivo , candesartan , in vitro , chemistry , pharmacology , resveratrol , flow cytometry , dose , microbiology and biotechnology , biochemistry , biology , receptor , angiotensin ii
Objectives: to analyze the cytogenetic parameters in vivo and in vitro in the administration of Resveratrol and Candesartan Cilexetil in different dosages and combinations. Material and methods. Male C57Bl/6 mice were used for the research. We investigated the molecular-biological parameters in vivo and in vitro and also the number of stem cells with CD117 phenotype (flow cytometry). The statistical analysis of the data was performed using Excel and Statistica. Results. Candesartan and Resveratrol in different dosages and combinations influence the molecular-biological parameters in vivo and in vitro . Candesartan at a dose of 3 mg/kg and its complex application with Resveratrol stimulate the formation of CD117 cells.