Open AccessProtective Effect of Udenafil Against Ischemia Reperfusion Injury Due to Testicular Torsion/Detorsion in Rat Model
Author(s) -
Zülfü Sertkaya,
Orhan Koca,
Metin İshak Öztürk,
Mehmet Akyüz,
Gülistan Gümrükçü,
Musab Ali Kutluhan,
Muhammet İhsan Karaman
Publication year - 2020
Publication title -
the eurasian journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.337
H-Index - 13
eISSN - 1308-8742
pISSN - 1308-8734
DOI - 10.5152/eurasianjmed.2020.19229
Subject(s) - medicine , testicular torsion , reperfusion injury , glutathione peroxidase , ischemia , endocrinology , anesthesia , urology , superoxide dismutase , oxidative stress , surgery
Testicular torsion causes migration of neutrophils to the ischemic region and formation of free oxygen radicals that have a critical effect on ischemic reperfusion (I/R) injury. Udenafil is a selective, strong, and reversible inhibitor of phosphodiesterase type enzyme. In our study, we evaluate the protective effect of udenafil against reperfusion injury due to I/R.