Open AccessNovel Expanding Renal Cell Carcinoma Biomarkers
Author(s) -
Francesco Claps,
Mònica Mir
Publication year - 2021
Publication title -
société internationale d'urologie journal
Language(s) - English
Resource type - Journals
ISSN - 2563-6499
DOI - 10.48083/xlqz8269
Subject(s) - renal cell carcinoma , liquid biopsy , medicine , disease , kidney cancer , asymptomatic , cancer , biomarker , proteomics , bioinformatics , intensive care medicine , biology , biochemistry , gene
Identification of reliable molecular biomarkers that can complement clinical practice represents a fascinating challenge in any cancer field. Renal tumors are usually asymptomatic and incidentally identified during imaging studies undertaken for unrelated causes. However, in 25% to 30% of patients the first diagnosis is accompanied by symptoms and associated with distant metastasis. Thus, early diagnosis may reduce the risk of disease progression also avoiding side effects of inadequate treatments. Moreover, the ability to categorize patients' risk of recurrence after radical treatment, or even predict benefit from a target therapy, represents a compelling challenge. Here we review the current state-of-the-art on RCC biomarkers, particularly focusing on the new approaches of genomics, liquid biopsy, proteomics, and metabolomics.