Open AccessPhytochemical and Antihypertensive Tests of Celery (Apium graveolens L.) and Garlic (Allium sativum L.) Formula
Author(s) -
Rida Rosa,
Harrizul Rivai
Publication year - 2021
Publication title -
international journal of pharmaceutical sciences and medicine
Language(s) - English
Resource type - Journals
ISSN - 2519-9889
DOI - 10.47760/ijpsm.2021.v06i07.004
Subject(s) - phytochemical , allium sativum , apium graveolens , phenols , traditional medicine , chemistry , blood pressure , distilled water , glycoside , medicine , botany , chromatography , biology , biochemistry , organic chemistry
Hypertension is also the leading cause of death worldwide. Treatment and control of hypertension help prevent cardiovascular death. Traditionally celery and garlic have been used as ingredients to lower high blood pressure by the people of South Sulawesi. Phytochemical testing was carried out to provide information about compounds' content in the formula of celery and garlic. Furthermore, the determination of the levels of alkaloids and saponins was carried out gravimetrically, the decision of the stories of phenols with a UV-Visible spectrophotometer, and the conclusion of the levels tannins with a UV spectrophotometer. Pharmacological testing using 25 white male rats were treated with doses of celery and garlic formula given to rats, namely 185 mg/ 200 g BW, 370 mg/ 200 g BW, 740 mg/ 200 g BW orally as test material. In the negative control, the rats were only given distilled water alone, and in the positive control, it was induced using 8% NaCl and 0.05% prednisone orally. The test solution was given for 21 days. The results of the phytochemical test showed that the celery and garlic ingredients contained positive alkaloids, saponins, phenols, tannins with levels of 1.8917 % alkaloids, 0.5885 % saponins, 1.6138 % phenols, and 1,3485 % tannins. Pharmacological test results showed systolic blood pressure and diastolic blood pressure decreased significantly (p < 0.05).