Open AccessIL-4 induces the formation of multinucleated giant cells and expression of β5 integrin in central giant cell lesion
Author(s) -
Amirala Aghbali,
Sona Rafieyan,
Leila Mohamed-Khosroshahi,
Behzad Baradaran,
Dariush Shanehbandi,
Maryam Kouhsoltani
Publication year - 2016
Publication title -
medicina oral, patología oral y cirugía bucal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 56
eISSN - 1698-6946
pISSN - 1698-4447
DOI - 10.4317/medoral.20935
Subject(s) - giant cell , central giant cell granuloma , integrin , monocyte , immunocytochemistry , pathology , immunohistochemistry , biology , microbiology and biotechnology , immunology , cell , chemistry , medicine , genetics
It is now well established that IL-4 has a central role in the development of monocytes to multinucleated giant cells (MGCs) by inducing the expression of integrins on the surface of monocytes. The aim of this study was to investigate the potential role of IL-4 in induction of β5 integrin expression in the peripheral blood samples of patients with giant cell granuloma.