Open AccessPNPLA3 and TM6SF2 polymorphisms in Brazilian patients with nonalcoholic fatty liver disease
Author(s) -
Quelson Coelho Lisboa,
Mateus Jorge Nardelli,
Pedro Paulo Pereira,
Débora Marques de Miranda,
Stephanie Nunes Ribeiro,
Raíssa Soares Neves da Costa,
Camila Azevedo Versiani,
Paula Vieira Teixeira Vidigal,
Teresa Cristina de Abreu Ferrari,
Cláudia Alves Couto
Publication year - 2020
Publication title -
world journal of hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 55
ISSN - 1948-5182
DOI - 10.4254/wjh.v12.i10.792
Subject(s) - medicine , nonalcoholic fatty liver disease , nonalcoholic steatohepatitis , disease , gastroenterology , fatty liver
Nonalcoholic fatty liver disease (NAFLD) is becoming the most common chronic liver disease worldwide, with significant morbidity associated with nonalcoholic steatohepatitis (NASH). Genome-wide association studies demonstrated that the variants rs738409 C/G in the PNPLA3 and rs58542926 C/T in the TM6SF2 genes are determinants of inter-individual and ethnicity-related differences in hepatic fat content and NAFLD progression.