Open AccessDirect interaction between Rab5a and Rab4a enhanced epidermal growth factor-stimulated proliferation of gastric cancer cells
Author(s) -
Guojun Cao,
Di Wang,
Zhao-Pei Zeng,
Guoxiang Wang,
Chunjiu Hu,
Zhifang Xing
Publication year - 2021
Publication title -
world journal of gastrointestinal oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 26
ISSN - 1948-5204
DOI - 10.4251/wjgo.v13.i10.1492
Subject(s) - carcinogenesis , cancer , cancer research , colocalization , epidermal growth factor , cell growth , epidermal growth factor receptor , cancer cell , cell culture , growth factor , vascular endothelial growth factor , biology , medicine , receptor , microbiology and biotechnology , genetics , vegf receptors
Gastric cancer (GC) is one of the leading causes of cancer-related death worldwide. Although targeted therapies such as antibodies against human epidermal growth factor receptor 2 or vascular endothelial growth factor receptor 2 have been widely used in the treatment of metastatic cancer, the overall outcomes are poor. Therefore, elucidation of the mechanism underlying cancer progression is important to improve prognosis. Overexpression of the Rab5a gene has been confirmed to correlate with tumorigenesis of many cancers, but the mechanism underling, especially of GC, is still unclear.