Open AccessInvestigation of CYP1B1 gene involvement in primary congenital glaucoma in Iraqi children
Author(s) -
Suzanne Jubair,
Salwa H.N. Al-Rubae'i,
Ali N. M. Al-Sharifi,
Ahmed AbdulJabbar Suleiman
Publication year - 2019
Publication title -
middle east african journal of ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.357
H-Index - 25
eISSN - 0975-1599
pISSN - 0974-9233
DOI - 10.4103/meajo.meajo_116_19
Subject(s) - cyp1b1 , missense mutation , genetics , gene , biology , mutation , allele , gene mutation , cytochrome p450 , enzyme , biochemistry
Primary congenital glaucoma (PCG) is a severe type of glaucoma that occurs early in life. PCG is usually inherited in an autosomal recessive pattern. Cytochrome P450, family 1, subfamily B, polypeptide 1 ( CYP1B1 ) gene is reported to be PCG-related gene. It codes for the CYP1B1 enzyme which is considered as phase I xenobiotic-metabolizing enzyme and its function is related to the eye oxidative homeostasis and correspondingly to the normal development of the eye. This is the first genetic study in Iraq that investigates the CYP1B1 polymorphisms behind the PCG disease.