Open AccessPrimary myelin oligodendrocyte glycoprotein-immunoglobulin G-associated optic neuritis presenting after a frozen embryo transfer
Author(s) -
Dana R. Siegel,
Thanh-Ha Luu,
Malgorzata E. Skaznik-Wikiel
Publication year - 2021
Publication title -
journal of human reproductive sciences
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.484
H-Index - 31
eISSN - 0974-1208
pISSN - 1998-4766
DOI - 10.4103/jhrs.jhrs_30_21
Subject(s) - medicine , optic neuritis , pathogenesis , multiple sclerosis , myelin oligodendrocyte glycoprotein , myelin , immunology , pregnancy , antibody , oligodendrocyte , pathology , central nervous system , experimental autoimmune encephalomyelitis , biology , genetics
Myelin oligodendrocyte glycoprotein (MOG)-immunoglobulin G-associated optic neuritis (ON) is a newly recognized antibody-mediated demyelinating disease of the central nervous system, resulting in acute visual loss and pain with eye movement. The effects of pregnancy on disease pathogenesis remain incompletely understood. Herein, we present a novel association between a frozen embryo transfer (FET) and the first manifestation of MOG-ON in a previously healthy patient with unexplained infertility. The patient presented with acute bilateral visual loss 3 weeks after a single FET and was found to test positive for MOG antibodies with an otherwise unremarkable workup. The patient's vision returned to baseline with high-dose intravenous methylprednisolone and therapeutic plasma exchange. This is the first published case highlighting an association between MOG-ON and assisted reproductive technology (ART) in a patient without prior risk factors. Further studies are needed to clarify the effects of ART and pregnancy in general on disease pathogenesis.