Open AccessOxaliplatin treatment and peripheral nerve damage in cancer patients
Author(s) -
Marta Banach,
Aneta L. Zygulska,
Krzysztof Krzemieniecki
Publication year - 2018
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_971_16
Subject(s) - oxaliplatin , medicine , neurotoxicity , peripheral neuropathy , colorectal cancer , folinic acid , subclinical infection , chemotherapy induced peripheral neuropathy , neurological examination , regimen , capecitabine , chemotherapy , anesthesia , gastroenterology , surgery , oncology , cancer , toxicity , diabetes mellitus , endocrinology
Oxaliplatin-induced neurotoxicity is the single main dose-limiting factor in the treatment of colorectal cancer. The degree of neurotoxicity may be either acute and reversible or observed as cumulative and chronic peripheral nerve damage leading to peripheral neuropathy (PNP), walking difficulties, extremity hypersensitivity, tingling and numbness, and increased pain sensation.