Open AccessmiR-146a is deregulated in gastric cancer
Author(s) -
Kamran Ghaedi,
Bahareh Adami,
Hossein Tabatabaeian,
Ardeshir Talebi,
Mansoureh Azadeh,
Elnaz Dehdashtian
Publication year - 2018
Publication title -
journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 1998-4138
pISSN - 0973-1482
DOI - 10.4103/jcrt.jcrt_855_17
Subject(s) - downregulation and upregulation , cancer , carcinogenesis , microrna , helicobacter pylori , cancer research , medicine , lymph node , oncology , biology , pathology , gene , biochemistry
Gastric cancer is one of the most significant reasons for cancer-related death. miR-146a is one of the dysregulated factors associated with gastric tumorigenesis. However, deregulation of this microRNA (miRNA) has become controversial. Moreover, the inflammation-mediating role of this miRNA implies that miR-146a might be dysregulated by gastric cancer-related pathogens, such as Helicobacter pylori. However, the dysregulation of miR-146a in H. pylori-infected gastric tumors has not been widely studied.
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