Open AccessTranscriptional elucidation of tumor necrosis factor-α-mediated nuclear factor-κB1 activation in breast cancer cohort of Pakistan
Author(s) -
Javeria Qadir,
Syeda Kiran Riaz,
Namood-e Sahar,
Durkhshan Aman,
Muhammad Jadoon Khan,
Muhammad Ehsan Malik
Publication year - 2020
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_484_18
Subject(s) - breast cancer , tumor necrosis factor alpha , cancer research , metastasis , downregulation and upregulation , cancer , estrogen receptor , tumor necrosis factor receptor 1 , medicine , biology , oncology , pathology , gene , tumor necrosis factor receptor , biochemistry
Initiation, promotion, progression, and metastasis of mammary tumors are mediated by dysregulation of multiple genes involved in various signaling pathways. Expressional variation of these molecules significantly influences cancer cell proliferation in breast cancer.