Open AccessSpecific inhibition of Notch1 signaling suppresses properties of lung cancer stem cells
Author(s) -
Haibo Cai,
Wei Lu,
Yueying Zhang,
Hengyao Liu,
Zhanhui Wang,
Yi Shen
Publication year - 2019
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/jcrt.jcrt_482_17
Subject(s) - cd44 , cancer stem cell , cancer research , stem cell , notch signaling pathway , lung cancer , biology , cd24 , a549 cell , microbiology and biotechnology , signal transduction , cell , medicine , genetics
Lung cancer is the leading cause of cancer-related death worldwide with a relatively low 5-year relative survival rate of 16%. Novel and efficient therapeutic approach for lung cancer is desperately needed.