Open AccessStatus of single nucleotide polymorphism of matrix gla protein gene (rs4236) in Nephrolithiasis: A preliminary study in indian population
Author(s) -
Anandan Murugesan,
Lakshman Kumar,
P Janarthanan
Publication year - 2018
Publication title -
international journal of applied and basic medical research/international journal of applied and basic medical research
Language(s) - English
Resource type - Journals
eISSN - 2248-9606
pISSN - 2229-516X
DOI - 10.4103/ijabmr.ijabmr_420_16
Subject(s) - single nucleotide polymorphism , genetics , gene , polymorphism (computer science) , biology , population , genotype , medicine , environmental health
Urine is a supersaturated solution with solutes in very high concentration. Matrix gla protein (MGP) is one of the proteins involved in inhibition of extracellular calcification. Among the various polymorphisms studied, polymorphism of SNP rs4236 in the MGP gene is found to have association with nephrolithiasis. We evaluated the significance of SNP rs4236 polymorphism in nephrolithiasis among the Indian population.