Open AccessAberrant p16INK4A methylation: Relation to viral related chronic liver disease and hepatocellular carcinoma
Author(s) -
Fatma El Mougy,
Mohammed Youssef,
Dalia Omran,
Sahar A. Sharaf,
Hany Elsayed,
Walaa Rabie,
Esraa Mowafy Mohamed,
Hany Elghobary
Publication year - 2014
Publication title -
south asian journal of cancer
Language(s) - English
Resource type - Journals
eISSN - 2278-4306
pISSN - 2278-330X
DOI - 10.4103/2278-330x.126498
Subject(s) - hepatocellular carcinoma , medicine , methylation , cirrhosis , gastroenterology , dna methylation , cancer , carcinoma , oncology , gene , biology , gene expression , biochemistry
Hepatocellular carcinoma (HCC) is currently the fifth most common solid tumor worldwide and the third leading cause of cancer related deaths. Several studies have shown that the tumor suppressor gene p16INK4A is frequently downregulated by aberrant methylation of the 5'-cytosine-phosphoguanine island within the promoter region.