Open AccessInfluence of genetic and environmental factors in peripheral arterial disease natural history: Analysis from six years follow up
Author(s) -
Silvana Archetti,
Manuela Martini,
Emanuele Botteri,
Diego Di Lorenzo,
Edoardo Cervi,
Stefano Bonardelli
Publication year - 2012
Publication title -
international journal of applied and basic medical research/international journal of applied and basic medical research
Language(s) - English
Resource type - Journals
eISSN - 2248-9606
pISSN - 2229-516X
DOI - 10.4103/2229-516x.106354
Subject(s) - medicine , methylenetetrahydrofolate reductase , disease , risk factor , genotype , arterial disease , prothrombin g20210a , genetic predisposition , homocysteine , allele , genetics , vascular disease , gene , biology
Peripheral arterial disease (PAD) is a disease affecting million of patients worldwide. Though traditional cardiovascular risk factors have been associated with the development of PAD, the possible existence of an inherited genetic predisposition to PAD has been investigated in few familial aggregation studies. A link between genetics and PAD may open new avenues for the prevention of this morbid and mortal disorder.