Open AccessRepeated dose of ketamine effect to the rat hippocampus tissue
Author(s) -
Mehtap Okyay Karaca,
Mustafa Süren,
Zafer İsmail Karaca,
Semih Arıcı,
Serkan Karaman,
Hüseyin Aslan,
Ziya Kaya,
Serkan Doğru
Publication year - 2015
Publication title -
saudi journal of anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.416
H-Index - 24
eISSN - 1658-354X
pISSN - 0975-3125
DOI - 10.4103/1658-354x.154726
Subject(s) - ketamine , hippocampus , hippocampal formation , neurotoxicity , saline , medicine , intraperitoneal injection , brain tissue , dentate gyrus , significant difference , anesthesia , endocrinology , toxicity
We aimed to determine the neurotoxic effect of repeated ketamine administration on brain tissue and if neurotoxic effect was present, whether this effect continued 16 days later using histological stereological method, a quantitative and objective method.