Open AccessNeonatal hepatitis with herpes simplex
Author(s) -
Rishika P. Sakaria,
Ira Shah,
Sushmita Bhatnagar
Publication year - 2016
Publication title -
medical journal of dr. d y patil university/medical journal of dr. d.y. patil university
Language(s) - English
Resource type - Journals
eISSN - 2278-7119
pISSN - 0975-2870
DOI - 10.4103/0975-2870.182521
Subject(s) - herpes simplex virus , medicine , hsl and hsv , virology , antiviral therapy , neonatal hepatitis , hepatitis , hepatitis a virus , disease , immunology , virus , liver transplantation , chronic hepatitis , transplantation , biliary atresia
We report two cases of neonatal hepatitis with herpes simplex virus (HSV) infection. Whether the HSV infection was the cause of hepatitis, or merely associated with it is not clear. While, in the first case, resolution could not be achieved despite high-dose antiviral treatment with acyclovir and liver transplant had to be advised; in the second case, there was complete resolution of the disease without antiviral therapy. Role of acyclovir in these children needs further assessment