Open AccessChemopreventive effect of carvacrol on 1,2-dimethylhydrazine induced experimental colon carcinogenesis
Author(s) -
S. Arivalagan,
S. Gunasekaran,
Namasivayam Nalini
Publication year - 2016
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.154925
Subject(s) - carvacrol , lipid peroxidation , aberrant crypt foci , superoxide dismutase , glutathione peroxidase , 1,2 dimethylhydrazine , azoxymethane , colorectal cancer , catalase , antioxidant , dimethylhydrazine , chemistry , medicine , glutathione , carcinogenesis , endocrinology , cancer , enzyme , biochemistry , food science , colonic disease , essential oil
Colorectal cancer (CRC) is a leading cause for cancer-related death and its prevention is of great importance throughout the world. Chemoprevention offers a novel approach to control the incidence of colon cancer. The present study was performed to evaluate the efficacy of carvacrol supplementation on colonic aberrant crypt foci (ACF), lipid peroxidation, and antioxidant defense system in 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis in male Wistar rats.