Open AccessFrequency of epidermal growth factor receptor mutations in Jordanian lung adenocarcinoma patients at diagnosis
Author(s) -
Natheir Obeidat,
Abdalla Awidi,
Nidaa A. Ababneh,
Maha Shomaf,
Tariq Al-Adaily,
Mohammad Jaber,
Mohammad Alkhateeb,
Salah Abbasi
Publication year - 2016
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.147711
Subject(s) - epidermal growth factor receptor , lung cancer , exon , adenocarcinoma , point mutation , medicine , somatic cell , mutation , cancer research , polymerase chain reaction , oncology , population , gene mutation , cancer , gene , biology , pathology , genetics , environmental health
Somatic mutations of the epidermal growth factor receptor (EGFR) gene have been associated with tumor response to tyrosine kinase inhibitors (TKIs) and favorable outcome in patients with non-small-cell lung cancer (NSCLC). The activating mutations that confer sensitivity to EGFR TKIs are present in the TK domain of the EGFR gene. This study aims to report on the prevalence of EGFR mutations in NSCLC and non-squamous lung cancer patients at diagnosis, using genomic deoxyribonucleic acid (DNA) obtained from paraffin-embedded tissue samples.